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PSMD10

Synonyms
dJ889N15.2, p28, p28(GANK)
External resources
Summary
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.

Variant counts

Variant classification counts according to ACMG guideline on all identified variants among our tested samples are listed. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
129
Likely benign
53
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on PSMD10 gene.

Phenotype class
Patients in 3billion (%)

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