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NCR3

Synonyms
1C7, CD337, LY117, MALS, NKp30
External resources
Summary
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
824
Likely benign
8,839
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on NCR3 gene.

Phenotype class
Patients in 3billion (%)

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