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MS4A12

Synonyms
Ms4a10
External resources
Summary
The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
848
Likely benign
658
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on MS4A12 gene.

Phenotype class
Patients in 3billion (%)

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