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KCNK6

Synonyms
K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2
External resources
Summary
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,286
Likely benign
932
Benign
481

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on KCNK6 gene.

Phenotype class
Patients in 3billion (%)

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