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IL17RB

Synonyms
CRL4, EVI27, IL17BR, IL17RH1
External resources
Summary
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
7,786
Likely benign
1,865
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on IL17RB gene.

Phenotype class
Patients in 3billion (%)

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