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IGFBP4

Synonyms
BP-4, HT29-IGFBP, IBP4, IGFBP-4
External resources
Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
460
Likely benign
349
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on IGFBP4 gene.

Phenotype class
Patients in 3billion (%)

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