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ICMT

Synonyms
HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT
External resources
Summary
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
2,566
Likely benign
248
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on ICMT gene.

Phenotype class
Patients in 3billion (%)

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