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GSTO1

Synonyms
GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R
External resources
Summary
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,345
Likely benign
956
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on GSTO1 gene.

Phenotype class
Patients in 3billion (%)

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