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FNDC5

Synonyms
FRCP2, irisin
External resources
Summary
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
2,797
Likely benign
420
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on FNDC5 gene.

Phenotype class
Patients in 3billion (%)

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