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DEDD2

Synonyms
FLAME-3, FLAME3
External resources
Summary
This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
2,372
Likely benign
80
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on DEDD2 gene.

Phenotype class
Patients in 3billion (%)

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