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DCAF6

Synonyms
1200006M05Rik, ARCAP, IQWD1, MSTP055, NRIP, PC326
External resources
Summary
The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
14,383
Likely benign
1,135
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on DCAF6 gene.

Phenotype class
Patients in 3billion (%)

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