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CCT6B

Synonyms
CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303
External resources
Summary
This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
7,206
Likely benign
1,111
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on CCT6B gene.

Phenotype class
Patients in 3billion (%)

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