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AMOTL2

Synonyms
LCCP
External resources
Summary
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
1,929
Likely benign
2,157
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on AMOTL2 gene.

Phenotype class
Patients in 3billion (%)

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