Home > Gene Browser > ADRA1D

ADRA1D

Synonyms
ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2
External resources
Summary
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
2,789
Likely benign
363
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on ADRA1D gene.

Phenotype class
Patients in 3billion (%)

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