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ADAM7

Synonyms
ADAM 7, ADAM-7, EAPI, GP-83, GP83
External resources
Summary
This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma.

Variant counts

The variants found in rare patients tested by 3billion are classified and counted according to ACMG guidelines. The variants with over 5% variant frequency in population genome databases ( gnomAD, dbSNP, etc) are excluded.

Pathogenic
0
Likely pathogenic
0
VUS
4,259
Likely benign
8,278
Benign
0

Patient phenotypes

No patients carry pathogenic or likely pathogenic variants on ADAM7 gene.

Phenotype class
Patients in 3billion (%)

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